Objective: Neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte
ratio (PLR), monocyte-lymphocyte ratio (MLR), mean platelet volume
(MPV), and systemic immune inflammation index (SII) are recently
used as indicators of inflammation. NLR, PLR, MLR, and MPV have
been evaluated in many studies in patients with schizophrenia and
bipolar disorder. However, there are no studies investigating SII. This
study aims to evaluate NLR, PLR, MLR, MPV and SII values and
complete blood count elements in patients hospitalized with diagnoses
of the schizophrenia with psychotic episode and bipolar disorder with
manic episode by comparing them with the control group.
Method: A total of 149 patients who were hospitalized with the
diagnoses of the schizophrenia with psychotic episode and bipolar
disorder with manic episode and who met the inclusion criteria were
included in our study where the control group was composed of 66
healthy individuals. White blood cell (WBC), neutrophil, lymphocyte,
platelet, and monocyte counts were obtained retrospectively from
complete blood counts at the time of admission, based on which NLR,
PLR, MLR, and SII were calculated.
Results: In this study, higher NLR, PLR, and SII values and lower
MPV and lymphocyte counts were observed in schizophrenia
patients compared to the control group. NLR, PLR, and SII values
and neutrophil counts were higher in patients with bipolar disorder
compared to the control group. Lower MPV values were found in
patients with schizophrenia compared to patients with bipolar disorder.
Conclusion: Simple inflammatory and SII values in our study indicate
the presence of low-grade systemic inflammation in schizophrenia and
bipolar disorder.
Keywords: Bipolar disorder, schizophrenia, inflammation, biomarkers,
laboratory