Osteogenesis imperfecta (OI) is a rare connective tissue disorder
characterized by bone fragility, growth retardation, hearing loss, and short
stature. Literature on the comorbidity of OI and psychotic disorders is
limited. Antipsychotic side effects such as hyperprolactinemia, sedation,
and orthostatic hypotension may increase fracture risk, presenting
challenges in comorbid cases. Here, we describe a 14-year-old male
with OI and schizophrenia. The patient presented with a three-month
history of irritability, self-harm, auditory hallucinations, and referential
delusions. His history included multiple fractures, leading to OI
diagnosis at age 8. He was admitted with acute psychotic disorder and
treated with aripiprazole 20 mg/day, resulting in significant symptom
improvement. No new bone fractures were observed during one year
of follow-up. This case highlights the management of comorbid OI
and schizophrenia. Fracture risk is a critical concern in OI patients.
Clinicians should carefully select antipsychotics in the presence of
psychosis and closely monitor patients to minimize adverse effects.
Keywords: Adolescent, antipsychotics, osteogenesis imperfecta,
schizophrenia, side effects