Major depressive disorder (MDD), with its heterogeneous nature and variable
course, poses significant challenges for clinicians in treatment planning and
clinical decision-making. These challenges are further compounded by the
rapid emergence of new treatment options and the uncertainty regarding
their place within clinical algorithms. In this context, structured treatment
guidelines that offer sequential, evidence-based recommendations based
on comparative evaluation of available interventions have become essential
reference tools for clinicians. Although various international guidelines offer
comprehensive recommendations, the absence of a locally relevant and
up-to-date guideline tailored to national clinical needs remains a critical
gap. This guideline was developed to address that gap, aiming to provide a
scientifically grounded and clinically applicable resource for the treatment
of depression in Türkiye.
This guideline reviews recent developments in MDD treatment and presents
evidence-based, sequential recommendations applicable to clinical practice
in Türkiye. It also systematically covers assessment tools, clinical subtypes,
outcome measures and decision-making processes that may guide treatment
planning. This article introduces the methodological framework, development
process and the core concepts and definitions related to the guideline.
Keywords: Psychometric rating, terminology, treatment of depression,
treatment resistance