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Lithium in the Treatment of Premenstrual Dysphoric Disorder: A Case Report

Rümeysa Ayşe GÜLLÜLÜ, Anıl MUŞTUCU, Cengiz AKKAYA
2024 35(4): 329-332
DOI: 10.5080/u27350
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İNGİLİZCE ÖZET

Premenstrual dysphoric disorder (PDD) is characterized by mental,
physical and cognitive symptoms that occurs in the late luteal phase of
the menstrual cycle and regresses in the week following menstruation.
In PDD, serotonin reuptake inhibitors and combined contraceptives are
the primary pharmacologic treatments. In cases where there is a personal
or family history of bipolar disorder (BD), the use of antidepressants
may pose a risk of inducing manic episodes. The frequent coexistence
of BD and PDD, the fact that both diseases are cyclic in nature and that
common mechanisms such as hormonal changes play a role in their
aetiologies, suggest that lithium might be efficacious in the treatment
of PDD. Here, we present a case who didn’t have a BD but a family
history of BD and was treated with lithium monotherapy for PDD with a
successful outcome. In cases where first- and second-line therapies cannot
be used or no response is obtained in PDD patients, pharmacological
agents that have demonstrated efficacy in preventing mood episodes
among first-degree relatives, may present a viable solution.
Keywords: Antidepressive Agents, Drug Therapy, Lithium,
Premenstrual Dysphoric Disorder, Premenstrual Syndrome