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Etiopathogenesis in the Development of Borderline Personality Characteristics in Children and Adolescents

Onat YETİM,Özhan YALÇIN
2024 35(2): 137-149
DOI: 10.5080/u26852
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İNGİLİZCE ÖZET

The validity and clinical significance of the characteristics of borderline
personality disorder (BPD) in adolescents are increasingly being recognized.
The persistence of BPD characteristics in adolescence is high and is
associated with negative interpersonal, academic, professional, and financial
outcomes. In the literature, BPD characteristics observed in children and
adolescents are explained with psychodynamic theories, developmental
models, and evolutionary approaches. Emotional dysregulation,
interpersonal dysfunction, impulsivity, and self-harming behavior, negative
life events, temperament characteristics, neuropsychological dysfunctions,
neuroanatomical, genetic, hormonal, and immunological factors may
play a role in BPD etiopathogenesis. This review aims to address different
approaches and relevant factors for the development of BPD. The articles
published between 1968-2021 in the PubMed database were reviewed,
and prominent studies were selected for evaluation. The importance of
invalidating environment, epistemic freezing and hypermentalization,
complex or attachment trauma is emphasized in psychodynamic and
developmental literature. In the evolutionary approach, on the other hand,
romantic relationships and the onset of reproduction are emphasized as
the reason for the emergence of symptoms during adolescence, and it is
argued that BPD is related to the rapid life history strategy. It is stated that a
decrease in volume in the orbitofrontal cortex and anterior cingulate cortex,
which are involved in top-down emotional processing, and an increase in
the activity of thalamus and hippocampus regions, which are involved in
bottom-up emotional processing are observed in adolescents with BPD
characteristics when compared to healthy controls. It is thought that the
increase in activation in the superior temporal gyrus and precuneus observed
in adolescents with BPD features is a neural indicator of hypermentalization,
and the increase in activation in the insula is a neural indicator of social pain.
It has been reported that the decrease in resting heart rate and the increase
in heart rate variability observed in adolescents with BPD symptoms are
associated with the activation of the parasympathetic system. BPD in
adolescents is a disorder that challenges clinicians in terms of diagnosis,
differential diagnosis, and treatment. It is crucial to evaluate the factors
related to etiopathogenesis in BPD in a multifaceted and detailed manner.
Keywords: Borderline Personality Disorder, Difficulty in Emotion
Regulation, Mentalization, Trauma, Self-harming Behavior, Temperamental
Characteristics