English
 
   
Letter to the Editor: CONVERGENCES AND DIVERGENCES IN THE ICD-11 VS. DSM-5 CLASSIFICATION OF MOOD DISORDERS

Arcangelo DI CERBO
2021 32(4): 293-295
DOI: 10.5080/u26899
[Geri]    [PDF]    [Özet]    [Yazara Mail]
İNGİLİZCE ÖZET

Dear Editor,
The chapter on mental, behavioural and neurodevelopmental
disorders of the 11th revision of the International Classification
of Diseases and Related Health Problems (ICD-11) has been
now finalized. Reporting of health statistics by Member States
to the World Health Organization (WHO) using the new
diagnostic system will begin in 2022.
The section on mood disorders of the ICD-11 is overall
consistent with the corresponding section of the ICD-10.
However, the definitions of a depressive and a manic episode
have been slightly changed, making them consistent with the
DSM-5 (see below), and an independent category of bipolar
II disorder has been introduced.
A significant effort has been made by the WHO and the
American Psychiatric Association to harmonize the diagnostic
systems they produce (the ICD-11 and the DSM-5). Indeed,
the organizational framework (“metastructure”) is now the
same in the two systems. Nonetheless, several intentional
differences between the two classifications remain, or have
emerged as a consequence of changes made in the DSM-
5. Here we briefly summarize the convergences and the
divergences between the ICD-11 and the DSM-5 regarding
the section on mood disorders (see Table 1).
A major convergence between the two diagnostic systems
regards the minimum number of symptoms required for
the diagnosis of major depression (“depressive episode” in
the ICD-11). In the ICD-11, contrary to the ICD-10, the
threshold for the diagnosis of depression is the same as in
the DSM: at least five depressive symptoms. However, the
ICD-11 requires at least five symptoms out of a list of ten
(instead of nine as in the DSM-5). The additional symptom
is “hopelessness”, which has been found to outperform more
than half of DSM symptoms in differentiating depressed
from non-depressed people (McGlinchey et al. 2006).
Table 1. Some Main Differences Between ICD-10, ICD-11 and DSM-5 Concerning the Diagnosis Of Mood Disorders
ICD-10 ICD-11 DSM-5
Threshold for diagnosis of depressive episode At least four out of ten
symptoms, two of which must
be depressed mood, loss of
interest and enjoyment, or
increased fatigability
At least five out of ten
symptoms, one of which
must be depressed mood or
diminished interest or pleasure
At least five out of nine
symptoms, one of which
must be depressed mood or
diminished interest or pleasure
The threshold for the diagnosis of depression is higher if
the person is bereaved
Not made explicit Yes No
Antidepressant-related mania qualifies as a manic episode No Yes Yes
Mixed episode is a separate diagnostic entity Yes Yes No
Dysthymia is a separate diagnostic entity Yes Yes No
Bipolar II disorder is a separate diagnostic entity No Yes Yes
“Qualifiers” (“specifiers”) for the diagnoses of mood
disorders are provided
No Yes Yes
CONVERGENCES AND DIVERGENCES
IN THE ICD-11 VS. DSM-5 CLASSIFICATION
OF MOOD DISORDERS
294
The ICD-11 is also following the DSM-5 in requiring the presence of increased activity or a subjective experience of increased energy, in addition to euphoria (or irritability or expansiveness), for the diagnosis of a manic episode, in order to reduce the chance of false positive cases. The two diagnostic systems also converge in considering that a manic or hypomanic syndrome arising during antidepressant treatment, and enduring beyond the known physiological effects of that treatment, qualifies as a manic or hypomanic episode. Bipolar II disorder has become an independent category in the ICD-11 (it was just mentioned as an example of “other bipolar affective disorders” in the ICD-10). Furthermore, for the first time, the ICD follows the DSM in introducing “qualifiers” (corresponding to DSM-5 “specifiers”) to the diagnoses of mood disorders, based on specific aspects of symptomatology or course.
There are, however, three important aspects in which the two diagnostic systems diverge. All of them are a consequence of changes made in the DSM-5 that the relevant ICD-11 Committee has regarded as not sufficiently supported by the available research evidence.
The first of these divergences concerns the issue of bereavement. In the ICD-11, in line with the DSM-IV and ICD-10 approach, it is stated that “a depressive episode should not be considered if the depressive symptoms are consistent with the normative response for grieving within the individual’s religious and cultural context”. However, the diagnosis of depression is not excluded if the person is bereaved; the diagnostic threshold is just raised, exactly as it happens in ordinary clinical practice. A depressive episode during bereavement is suggested by the persistence of symptoms for at least one month, and the presence of at least one symptom which is unlikely to occur in normal grief (such as extreme beliefs of low self-worth or guilt not related to the lost loved one, presence of psychotic symptoms, suicidal ideation, or psychomotor retardation). In contrast, the special status conferred by the DSM-IV to bereavement among life stressors has been eliminated in the DSM-5. However, two independent follow-up studies (Mojtabai 2011, Wakefield and Schmitz 2012) have reported that, in people with baseline bereavement-related depression, the risk for the occurrence of a further depressive episode during follow-up is significantly lower than in individuals with baseline non-bereavement-related depression, and not significantly different from the risk of people without a baseline history of depression to develop a first depressive episode during follow-up. This research evidence strongly supports the ICD-11 (and DSM-IV) approach. Furthermore, an intensive public debate has highlighted the consequences that the DSM-5 approach to the bereavement issue could have in several cultures, including a high rate of false positives and a trivialization of the concept of depression and consequently of mental disorder (Kleinman 2012).
A second divergence between the ICD-11 and DSM-5 sections on mood disorders concerns mixed states. The category of mixed episode is kept in the ICD-11, defined by several prominent manic and depressive symptoms which either occur simultaneously or alternate very rapidly (from day to day or within the same day) during a period of at least two weeks. The mood state is altered throughout the episode (i.e., the mood should be depressed, dysphoric, euphoric or expansive for at least two weeks). When depressive symptoms predominate, common contrapolar symptoms are irritability, racing or crowded thoughts, increased talkativeness, and increased activity. When manic symptoms predominate, common contrapolar symptoms are dysphoric mood, expressed beliefs of worthlessness, hopelessness, and suicidal ideation. This definition is in line with the ICD-10 and completely consistent with both classic and recent research evidence, as well as with clinical experience. In contrast, the DSM-5 solution to eliminate the category of mixed episode and to introduce a specifier “with mixed features”, applicable to manic, hypomanic and depressive episodes, has had the consequence to reduce the visibility of “mixity” in ordinary clinical practice (especially since the specifier is not codable, and is therefore at risk of not being recorded in clinical settings). Moreover, the DSM-5 definition of major depression with mixed features, requiring the presence of at least three “classic” manic symptoms (such as elevated mood, grandiosity, and increased involvement in risky activities) has been criticized for being inconsistent with the concept of mixed depression as delineated in both the classic and recent literature (e.g., Koukopoulos and Sani 2014).
A third divergence between the two diagnostic systems consists in the fact that the ICD-11 has not followed the DSM-5 in combining dysthymic disorder and chronic major depressive disorder into a single category (“persistent depressive disorder”). In fact, the relevant ICD-11 Committee expert considered that the evidence that the two disorders represent the same condition, to be addressed therapeutically in the same way, is insufficient. The category of dysthymic disorder is kept in the ICD-11, while a qualifier “current episode persistent” is to be used when the diagnostic requirements for depressive episode have been met continuously for at least the past two years.
For a discussion of other aspects of the classification of mood disorders, with the relevant therapeutic implications, as well as for information about the differences between the ICD-11 and the DSM-5 concerning other sections of the classification of mental disorders, we refer the reader to previous contributions (Demyttenaere et al. 2015, Fried et al. 2016, Haroz et al. 2017, Boschloo et al. 2019, Bryant 2019, Forbes et al. 2019, Fusar-Poli et al. 2019, Gureje et al. 2019,
295
Received: 13.09.2021, Accepted: 19.09.2021, Available Online Date: 30.11.2021
MD., University of Campania L. Vanvitelli, WHO Collaborating Centre for Research and Training in Mental Health, Naples, Italy.
Dr. Arcangelo Di Cerbo, e-mail: ardice77@gmail.com
https://doi.org/10.5080/u26899
Reed et al. 2019, Kendall 2019, van Os et al. 2019, Cuijpers et al. 2020, Fava and Guidi 2020, Gaebel et al. 2019, 2020, Hasler 2020, Jarrett 2020, Kato et al. 2020, Maj et al. 2020, Reynolds 2020, Sanislow 2020, Stein et al. 2020).
An International Advisory Group has been established to supervise the activities of translation, training of professionals and implementation of the ICD-11 chapter on mental disorders (see Giallonardo 2019, Pocai 2019, Perris 2020). The experience in the field will tell whether the above divergences from the DSM-5 in the ICD-11 classification of mood disorders are justified. Indeed, divergences in the description of the same mental health condition may sometimes be useful in order to allow the empirical comparison of different approaches to issues that are controversial.
Arcangelo DI CERBO
REFERENCES
Boschloo L, Bekhuis E, Weitz ES et al (2019) The symptom-specific efficacy of antidepressant medication vs. cognitive behavioral therapy in the treatment of depression: results from an individual patient data meta-analysis. World Psychiatry 18:183-91.
Bryant RA (2019) Post-traumatic stress disorder: a state-of-the-art review of evidence and challenges. World Psychiatry 18:259-69.
Cuijpers P, Noma H, Karyotaki E et al (2020) A network meta-analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression. World Psychiatry 19:92-107.
Demyttenaere K, Donneau AF, Albert A et al (2015) What is important in being cured from depression? Discordance between physicians and patients (1). J Affect Disord 174:390-6.
Fava GA, Guidi J (2020) The pursuit of euthymia. World Psychiatry 19:40-50.
Fried EI, Epskamp S, Nesse RM et al (2016) What are “good” depression symptoms? Comparing the centrality of DSM and non-DSM symptoms of depression in a network analysis. J Affect Disord 189:314-20.
Forbes MK, Wright AGC, Markon KE et al (2019) The network approach to psychopathology: promise versus reality. World Psychiatry 18:272-3.
Fusar-Poli P, Solmi M, Brondino N et al (2019) Transdiagnostic psychiatry: a systematic review. World Psychiatry 8:192-207.
Gaebel W, Reed GM, Jakob R (2019) Neurocognitive disorders in ICD-11: a new proposal and its outcome. World Psychiatry 18:232-3.
Gaebel W, Stricker J, Riesbeck M et al (2020) Accuracy of diagnostic classification and clinical utility assessment of ICD-11 compared to ICD-10 in 10 mental disorders: findings from a web-based field study. Eur Arch Psychiatry Clin Neurosci 270:281-9.
Giallonardo V (2019) ICD-11 sessions within the 18th World Congress of Psychiatry. World Psychiatry 18:115-6.
Gureje O, Lewis-Fernandez R, Hall BJ et al (2019) Systematic inclusion of culture-related information in ICD-11. World Psychiatry 18:357-8.
Haroz EE, Ritchey M, Bass JK et al (2017) How is depression experienced around the world? A systematic review of qualitative literature. Soc Sci Med 183:151-62.
Hasler G (2020) Understanding mood in mental disorders. World Psychiatry 19:56-7.
Jarrett RB (2020) Can we help more? World Psychiatry 19:246-7.
Kato TA, Kanba S, Teo AR (2020) Defining pathological social withdrawal: proposed diagnostic criteria for hikikomori. World Psychiatry 19:116-7.
Kendall T (2019) Outcomes help map out evidence in an uncertain terrain, but they are relative. World Psychiatry 18:293-5.
Kleinman A (2012) Culture, bereavement, and psychiatry. Lancet 379:608-9.
Koukopoulos A, Sani G (2014) DSM-5 criteria for depression with mixed features: a farewell to mixed depression. Acta Psychiatr Scand 129:4-16.
Kotov R, Jonas KG, Carpenter WT et al (2020) Validity and utility of Hierarchical Taxonomy of Psychopathology (HiTOP): I. Psychosis superspectrum. World Psychiatry 19:151-72.
Maj M, Stein DJ, Parker G et al (2020) The clinical characterization of the adult patient with depression aimed at personalization of management. World Psychiatry 19:269-93.
McGlinchey JB, Zimmerman M, Young D et al (2006) Diagnosing major depressive disorder VIII. Are some symptoms better than others? J Nerv Ment Dis 194:785-90.
Mojtabai R (2011) Bereavement-related depressive episodes: characteristics, 3-year course, and implications for the DSM-5. Arch Gen Psychiatry 68:920-8.
Perris F (2020) ICD-11 sessions at the 19th World Congress of Psychiatry. World Psychiatry 19:263-4.
Pocai B (2019) The ICD-11 has been adopted by the World Health Assembly. World Psychiatry 18:371-2.
Reed GM, First MB, Kogan CS et al (2019) Innovations and changes in the ICD-11 classification of mental, behavioural and neurodevelopmental disorders. World Psychiatry 18:3-19.
Reynolds CF 3rd (2020) Optimizing personalized management of depression: the importance of real-world contexts and the need for a new convergence paradigm in mental health. World Psychiatry 19:266-8.
Sanislow CA (2020) RDoC at 10: changing the discourse for psychopathology. World Psychiatry 19:311-2.
Stein DJ, Szatmari P, Gaebel W et al (2020) Mental, behavioural and neurodevelopmental disorders in the OCD-11: an international perspective on key changes and controversies. BMC Med 18:21.
van Os J, Guloksuz S, Vijn TW et al (2019) The evidence-based group-level symptom-reduction model as the organizing principle for mental health care: time for change? World Psychiatry 18:88-96.
Wakefield JC, Schmitz MF (2012) Recurrence of bereavement-related depression: evidence for the validity of the DSM-IV bereavement exclusion from the Epidemiologic Catchment Area Study. J Ment Dis 200:480-5.